WebFGF23 expression and function in vivo. We previously showed that osteoblast/osteocyte–specific flox-Fgf23 recombination using Dmp1-Cre suppressed circulating bioactive, intact FGF23 (iFGF23) in mice with normal renal function (47). Importantly, this animal was resistant to increasing FGF23 following high-phosphate … WebJul 15, 2024 · Osteocytes also govern phosphate homeostasis through the production of fibroblast growth factor 23 (FGF23), which lowers serum phosphate levels by increasing renal phosphate excretion and reducing the synthesis of 1,25-dihydroxyvitamin D (1,25 (OH) 2 D), an active metabolite of vitamin D.
Frontiers Roles of osteocytes in phosphate metabolism
WebRecent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). WebNational Center for Biotechnology Information caravane jayco
Frontiers Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 ...
WebChronic kidney disease is a health problem whose prevalence is increasing worldwide. The kidney plays an important role in the metabolism of minerals and bone health and therefore, even at the early stages of CKD, disturbances in bone metabolism are observed. In the course of CKD, various bone turnover or mineralization disturbances can develop … WebAug 10, 2024 · Figure 1. Possible factors and pathways associated with the involvement of TGF-β in chronic kidney disease-mineral and bone disorder. Increasing TGF-β levels accompanied by renal dysfunction induces mineral metabolism disturbance and bone remodeling. The detailed mechanisms and interactions are described in the text. WebSep 22, 2009 · Derangements in serum phosphate level result in rickets/osteomalacia or ectopic calcification indicating that healthy people without these abnormalities maintain … caravane islam