Phosphopantetheine-binding protein

Author: yczk

August undefined, 2024

WebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal domains of... Web[0005] This invention relates to a method of treatment, in particular to a method for lowering blood pressue levels in mammals and to compounds and compositions for use in such me

Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP …

WebJul 31, 2014 · Acyl carrier proteins (ACPs) are universal and highly conserved domains central to both fatty acid and polyketide biosynthesis. These proteins tether reactive acyl intermediates with a swinging 4′-phosphopantetheine (Ppant) arm and interact with a suite of catalytic partners during chain transport and elongation while stabilizing the growing … WebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement … easley cemetery townley alabama

Proteomics of Streptococcus mutans to Reveal the Antibiofilm …

WebOct 23, 2013 · The results suggest that some type I domains covalently incorporated in multidomain contexts possess potential protein binding sites missing in the equivalent regions of their respective structural templates. ... This 1136 residue long sequence is atypical since it does not possess a recognizable phosphopantetheine binding domain … WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … easley car dealerships

4′-Phosphopantetheine and Coenzyme A Biosynthesis in Plants*

Structural and binding studies of phosphopantetheine

WebApr 26, 2024 · This protein belongs to the phosphopantetheine attachment site (IPR006162) and other protein classes of databases InterPro, pfam, and TIGRfam like srf AA. The genome also possesses gene srf AD (729 bp) encodes for the thioesterase domain-containing protein comprising 242 amino acids. WebAug 31, 2015 · In vitro experiments have shown that in addition to vitamin B5, pantetheine can also be phosphorylated by pantothenate kinase activity, and the formed product, 4′-phosphopantetheine, can serve as... easley cattle company cantonWebMay 30, 2024 · FIGURE 2.(A) Structural superposition of apo Mab PPAT in complex with feed-back inhibitor CoA (grey), PDB code 7YXZ and product dpCoA (green), PDB code 5O08, showing conformational differences in the enzyme and ligand binding mode.(B) The pantetheine moiety of CoA adopts a similar conformation to that of dpCoA. However, the … easley cattle company canton tx

"WebJun 6, 2024 · Unique CFP (cysteine-free protein; 120 aa) has been identified as an extraordinary virulence factor in Beauveria bassiana (Cordycipitaceae), a main source of wide-spectrum fungal insecticides. Its homologs exclusively exist in wide-spectrum insect pathogens of Hypocreales, suggesting their importance for a fungal insect-pathogenic … " - Phosphopantetheine-binding protein

Phosphopantetheine-binding protein

WebPlease help us improve further — take a moment to fill our brief user survey. WebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ...

Did you know?

WebJun 3, 2010 · Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with 4'-phosphopantetheine. ... Find proteins for P9WPA5 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPA5 . Go to UniProtKB: P9WPA5. Entity Groups Sequence Clusters: WebSep 19, 2024 · Phosphopantetheinylation is an essential post-translational protein modification to primary and secondary metabolic pathways that ensures bacterial cell …

WebNov 4, 2024 · tyrosine-protein kinase is fine as a protein name but capsular polysaccharide biosynthesis would be more appropriate as a function. RimM protein, required for 16S … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl …

WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. WebBinding to a protein. ... 4'-Phosphopantetheinyl transferases (PPTs) catalyze the transfer of 4'-phosphopantetheine (4-PP) from coenzyme A to a conserved serine residue of their protein substrates. In humans, the number of pathways utilizing the 4-PP post-translational modification is limited and may only require a single broad specificity PPT ...

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas ...

WebPhosphopantetheine-binding protein Imported. Gene names. ORF names. C4F17_18890 Imported. Organism names. Organism. Variovorax sp. PMC12 Imported. Taxonomic identifier. 2126319 NCBI. Taxonomic lineage. Bacteria > Proteobacteria > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax. ... Similar … easley cattle trailers for saleWebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … ct 発泡剤WebAlthough holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al.in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. easley center at rose parkWebLegend. Settings. Analysis easley cbdWebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. ct 癌転移WebJan 18, 1999 · Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide-binding fold that is structurally similar to that in class I aminoacyl-tRNA synthetases. Superposition of bound adenylyl moieties from dPCoA in PPAT and ATP in aminoacyl-tRNA synthetases suggests nucleophilic attack by the 4'-phosphopantetheine … ct 発展WebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond ( Crawford et al. 2008; Meier et al. 2010; Roujeinikova et al. 2002 ). easley cfs